Sialic Acid Aldolase from Escherichia coli K12, Recombinant

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Cat No.

NATE-0475

Description

In enzymology, a N-acetylneuraminate lyase (EC 4.1.3.3) is an enzyme that catalyzes the chemical reaction:N-acetylneuraminate↔ N-acetyl-D-mannosamine + pyruvate. Hence, this enzyme has one substrate, N-acetylneuraminate, and two products, N-acetyl-D-mannosamine and pyruvate. This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. This enzyme participates in aminosugars metabolism.

Abbr

NALase, Recombinant (E. coli K12)

Alias

NPL; NALase; NANA lyase

Source

E. coli BL21

Species

Escherichia coli K12

Applications

Sialic acid aldolase can be used to synthesize unnatural sugars of C (6) to C (10) for the design of antagonists and inhibitors of glycoenzymes.

Product Overview

Sialic acid aldolases, or N-acetylneuraminate lyases, catalyze the reversible aldol cleavage of N-acetylneuraminic acid to form pyruvate and N-acetyl-D-mannosamine. In nature, N-acetylneuraminate lyase mainly occurs in pathogens.

Form

Lyophilized powder containing Tris-HCl and NaCl

Enzyme Commission Number

EC 4.1.3.3

Activity

> 3.0 units/mg protein

CAS_No

9027-60-5

Unit Definition

One unit will catalyze the formation of 1.0 μmol Neu-5-Ac from Man-N-Ac and pyruvate per minute at 37°C at pH 8.0.

Storage

−20°C

Synonyms

EC 4.1.3.3; Sialic Acid Aldolase; N-Acetylneuraminate lyase; N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming); N-acetylneuraminic acid aldolase; acetylneuraminate lyase; sialic aldolase; sialate lyase; N-acetylneuraminic aldolase; neuraminic aldolase; N-acetylneuraminate aldolase; neuraminic acid aldolase; N-acetylneuraminic acid aldolase; neuraminate aldolase; N-acetylneuraminic lyase; N-acetylneuraminic acid lyase; NPL; NALase; NANA lyase; acetylneuraminate pyruvate-lyase; N-acetylneuraminate pyruvate-lyase

"NALase" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-1850	N-Acetyl-D-Neuraminic Acid Aldolase (Crude Enzyme)	EC 4.1.3.3	9027-60-5	E. coli	Inquiry
DIA-182	Native Microorganism N-Acetylneuraminic acid aldolase	EC 4.1.3.3	9027-60-5	Microorganism	Inquiry
NATE-0490	Native Escherichia coli N-Acetylneuraminic Acid Aldolase	EC 4.1.3.3	9027-60-5	Escherichia coli	Inquiry
EXWM-4908	N-acetylneuraminate lyase	EC 4.1.3.3	9027-60-5		Inquiry

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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