xanthine dehydrogenase

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Cat No.

EXWM-1082

Description

Acts on a variety of purines and aldehydes, including hypoxanthine. The mammalian enzyme can also convert all-trans retinol to all-trans-retinoate, while the substrate is bound to a retinoid-binding protein. The enzyme from eukaryotes contains [2Fe-2S], FAD and a molybdenum centre. The mammalian enzyme predominantly exists as the NAD-dependent dehydrogenase (EC 1.17.1.4). During purification the enzyme is largely converted to an O2-dependent form, xanthine oxidase (EC 1.17.3.2). The conversion can be triggered by several mechanisms, including the oxidation of cysteine thiols to form disulfide bonds [which can be catalysed by EC 1.8.4.7, enzyme-thiol transhydrogenase (glutathione-disulfide) in the presence of glutathione disulfide] or limited proteolysis, which results in irreversible conversion. The conversion can also occur in vivo.

Form

Liquid or lyophilized powder

Enzyme Commission Number

EC 1.17.1.4

CAS_No

9054-84-6

Storage

Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.

Synonyms

NAD+-xanthine dehydrogenase; xanthine-NAD+ oxidoreductase; xanthine/NAD+ oxidoreductase; xanthine oxidoreductase

Reaction

xanthine + NAD+ + H2O = urate + NADH + H+

Notes

This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.

"XDH" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-1064	Native Xanthine dehydrogenase from Microorganism	EC 1.17.1.4	9054-84-6	Microorganism	Inquiry
NATE-1065	Native Xanthine Dehydrogenase from Bovine milk	EC 1.17.1.4	9054-84-6	Bovine milk	Inquiry

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