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IDE

Official Full Name
IDE
Background
Insulin Degrading Enzyme (IDE) is a large zinc-binding protease of the M16A metalloprotease subfamily known to cleave multiple short polypeptides that vary considerably in sequence. IDE was first identified by its ability to degrade the B chain of the hormone insulin. This activity was observed over sixty years ago, though the enzyme specifically responsible for B chain cleavage was identified more recently. This discovery revealed considerable amino acid sequence similarity between IDE and the previously characterized bacterial protease pitrilysin, suggesting a common proteolytic mechanism.
Synonyms
IDE; Insulin-degrading enzyme; insulysin; insulin protease

Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogEXWM-4338
ProductNameinsulysin
EC No.EC 3.4.24.56
CAS No.9013-83-6
Source
CatalogNATE-0849
EC No.EC 3.4.24.56
CAS No.
SourceS. frugiperda

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