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Matrix Metalloproteinase 3

Official Full Name
Matrix Metalloproteinase 3
Background
Matrix metalloproteinase-3 (MMP-3) also known as stromelysin-1 and transin (EC 3.4.24.17) cleaves a number of substrates including cartilage proteoglycan, collagen types II, III, IV, V and IX, fibronectin, laminin, and can activate MMP 1. MMP-3 is secreted as 57 and 59 kDa proenzymes and can be activated in vitro by organomercurials (e.g., 4 aminophenylmercuric acetate, APMA) and in vivo by proteases via intermediate forms to a 45 kDa active MMP 3 enzyme. Further autolysis to a 28 kDa form can also occur. MMP-3 is thought to play an important role in pathophysiological degradation processes associated with conditions such as rheumatoid arthritis and cancer cell invasion.
Synonyms
Stromelysin 1; EC 3.4.24.17; matrix metalloproteinase 3; proteoglycanase; collagenase activating protein; procollagenase activator; transin; MMP-3; neutral proteoglycanase; stromelysin; collagen-activating protein

Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogEXWM-4298
ProductNamestromelysin 1
EC No.EC 3.4.24.17
CAS No.79955-99-0
Source
CatalogNATE-0861
EC No.EC 3.4.24.17
CAS No.79955-99-0
Source
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