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α(1-3,4) Fucosidase from Sweet almond, Recombinant

Cat No.
NATE-1264
Description
Alpha-Fucosidase is an enzyme that breaks down fucose. Fucosidosis is an autosomal recessive lysosomal storage disease caused by defective alpha-L-fucosidase with accumulation of fucose in the tissues. Different phenotypes include clinical features such as neurologic deterioration, growth retardation, visceromegaly, and seizures in a severe early form; coarse facial features, angiokeratoma corporis diffusum, spasticity and delayed psychomotor development in a longer surviving form; and an unusual spondylometaphyseoepiphyseal dysplasia in yet another form.
Abbr
FUCA, Recombinant (Sweet almond tree)
Alias
FUCA
Source
Pichia pastoris
Species
Sweet almond tree
Product Overview
α1-3,4 Fucosidase, (also known as AMF) is a broad specificity exoglycosidase that catalyzes the hydrolysis of α1-3 and α1-4 linked fucose residues from oligosaccharides and glycoproteins.
Form
20 mM Tris-HCl (pH 7.5), 50 mM NaCl and 1 mM EDTA
Activity
75,000 units/mg
Molecular Weight
56000 daltons
Concentration
4,000 units/ml
Unit Definition
One unit is defined as the amount of enzyme required to cleave > 95% of the α-fucose from 1 nmol of Galβ1-4GlcNAcβ1-3(Fucα1-3)Galβ1- 4Glc-7-amino-4-methyl-coumarin (AMC), in 1 hour at 37°C in a total reaction volume of 10 μl.
Storage
4°C
Synonyms
α-L-fucoside fucohydrolase; Alpha-Fucosidase; FUCA1; FUCA; EC 3.2.1.51
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