Isocitrate dehydrogenase (NAD+) from Bacteria, Recombinant

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Cat No.

NATE-1041

Description

Isocitrate dehydrogenase (IDH) is an enzyme that catalyzes the oxidative decarboxylation of Isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of Isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms:IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cofactor instead of NAD+. They localize to the cytosol as well as the mitochondrion and peroxisome.

Abbr

IDH (NAD+), Recombinant (Bacteria)

Alias

IDH

Source

E. coli

Species

Bacteria

Form

Lyophilized powder

Enzyme Commission Number

EC 1.1.1.41

Activity

> 40 Units / mg

CAS_No

9001-58-5

Contaminants

Isocitrate dehydrogenase (NADP+) < 5%

Molecular Weight

40 kD (SDS-PAGE)

pH Stability

5.5 - 8.0

Optimum pH

8.0 - 9.0

Optimum temperature

60°C

Thermal stability

<45°C

Storage

Below -20°C

Synonyms

Beta-ketoglutaric-isocitric carboxylase; IDH; Isocitrate dehydrogenase (NAD); Isocitric acid dehydrogenase; Isocitric dehydrogenase; NAD dependent Isocitrate dehydrogenase; NAD Isocitrate dehydrogenase; NAD isocitric dehydrogenase; NAD-linked Isocitrate dehydrogenase; NAD-specific Isocitrate dehydrogenase; Nicotinamide adenine dinucleotide Isocitrate dehydrogenase; EC 1.1.1.41

"IDH" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-1103	Isocitrate dehydrogenase from Bacillus subtilis, Recombinant	EC 1.1.1.42	9028-48-2	Bacillus subtilis	Inquiry
NATE-1649	Mutant Isocitrate Dehydrogenase 1 R132H from Human, Recombinant			E. coli	Inquiry
NATE-0350	Native Porcine Isocitric Dehydrogenase (NADP)	EC 1.1.1.42	9028-48-2	Porcine heart	Inquiry
NATE-0351	Isocitrate Dehydrogenase (NADP+) from Yeast, Recombinant	EC 1.1.1.42	9028-48-2	Pichia pastoris	Inquiry

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