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Isocitrate dehydrogenase (NAD+) from Bacteria, Recombinant


Cat No.
NATE-1041
Description
Isocitrate dehydrogenase (IDH) is an enzyme that catalyzes the oxidative decarboxylation of Isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of Isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms:IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cofactor instead of NAD+. They localize to the cytosol as well as the mitochondrion and peroxisome.
Abbr
IDH (NAD+), Recombinant (Bacteria)
Alias
IDH
Source
E. coli
Species
Bacteria
Form
Lyophilized powder
Enzyme Commission Number
EC 1.1.1.41
Activity
> 40 Units / mg
CAS No.
9001-58-5
Contaminants
Isocitrate dehydrogenase (NADP+) < 5%
Molecular Weight
40 kD (SDS-PAGE)
pH Stability
5.5 - 8.0
Optimum pH
8.0 - 9.0
Optimum temperature
60°C
Thermal stability
<45°C
Storage
Below -20°C
Synonyms
Beta-ketoglutaric-isocitric carboxylase; IDH; Isocitrate dehydrogenase (NAD); Isocitric acid dehydrogenase; Isocitric dehydrogenase; NAD dependent Isocitrate dehydrogenase; NAD Isocitrate dehydrogenase; NAD isocitric dehydrogenase; NAD-linked Isocitrate dehydrogenase; NAD-specific Isocitrate dehydrogenase; Nicotinamide adenine dinucleotide Isocitrate dehydrogenase; EC 1.1.1.41
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