Native Human Cathepsin B

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Cat No.

NATE-0169

Description

Cathepsin B has been found to cleave procaspase 1 and procaspase 11 and to induce apoptosis in digitonin-permeabilized cells. Translocation of cathepsin B from the cytoplasm to the nucleus contributes to bile salt induced apoptosis of rat hepatocytes. Levels of cathepsin B in PC12 cells significantly decrease 12 to 24 hours after apoptosis is induced.

Abbr

CTSB, Native (Human)

Alias

CTSB; APPS; CPSB

Source

Human placenta

Species

Human

Applications

Cathepsin B is a lysosomal cysteine proteinase which hydrolyzes proteins with a broad specificity for peptide bonds. Cathepsin B may be a useful tool in Alzheimer’s research, as it may have a role in the natural defense against the disease. Cathepsin B may be used to cleave procaspase 1 and procaspase 11, and to induce apoptosis in digitonin-permeabilized cells.

Form

Lyophilized powder containing phosphate buffer salts

Enzyme Commission Number

EC 3.4.22.1

Activity

> 5 units/mg protein

CAS_No

9047-22-7

Composition

Protein, ~50% Lowry

Unit Definition

One unit will liberate 1 nanomole of 7-amino-4-methylcoumarin from Z-Arg-Arg 7-amido-4-methylcoumarin per min at pH 6.0 at 40°C.

Pathway

Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Toll Receptor Cascades, organism-specific biosystem

Function

cysteine-type endopeptidase activity; cysteine-type peptidase activity; kininogen binding; peptidase activity; peptide binding; protein binding

Synonyms

CTSB; cathepsin B; cathepsin B1; APPS; CPSB; EC 3.4.22.1; 9047-22-7; cathepsin II; CatB

"Cathepsin B" Total Products Page

Enzymes

Catalog	Product Name	EC No.	CAS No.	Source	Price
NATE-1706	Cathepsin B from Human, recombinant	EC 3.4.22.1	9047-22-7	E. coli	Inquiry
NATE-0167	Native Bovine Cathepsin B		9047-22-7	Bovine spleen	Inquiry
NATE-0168	Native Human Cathepsin B	EC 3.4.22.1	9047-22-7	Human liver	Inquiry
EXWM-4192	cathepsin B	EC 3.4.22.1	9047-22-7		Inquiry

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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