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CTSS

Official Full Name
CTSS
Background
Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicate that cathepsin S generates amyloid beta-peptide from amyloidogenic fragments of amyloid precursor protein (APP) in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease and Down Syndrome.
Synonyms
CTSS; cathepsin S; EC 3.4.22.27; FLJ50259; MGC3886

Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogNATE-1702
EC No.EC 3.4.22.27
CAS No.71965-46-3
SourceE. coli
CatalogEXWM-4201
ProductNamecathepsin S
EC No.EC 3.4.22.27
CAS No.71965-46-3
Source
CatalogNATE-0178
EC No.EC 3.4.22.27
CAS No.
SourceHuman spleen
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