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3-Deazaneplanocin

Cat No.
CEI-0477
Description
A lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.
Alias
DZNep; NSC 617989
Appearance
White solid
Product Overview
A lysine methyltransferase EZH2 (KMT63) inhibitor
CAS No.
102052-95-9
Molecular Weight
1202.6
Purity
>99%
Storage
-20 centigrade
Synonyms
DZNep; NSC 617989
Targets
EZH2
Molecular Formula
C12H24N4O3
Chemical Name
5R-​(4-​amino-​1H-​imidazo[4,​5-​c]pyridin-​1-​yl)-​3-​(hydroxymethyl)-​3-​cyclopentene-​1S,​2R-​diol
Solubility
DMSO and EtOH
Shipping Conditions
Gel pack
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