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5-hydroxyfuranocoumarin 5-O-methyltransferase

Cat No.
EXWM-1970
Description
Converts bergaptol into bergapten, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities. The enzyme methylates the 5-hydroxy group of some hydroxy- and methylcoumarins, such as 5-hydroxyxanthotoxin, but has little activity on non-coumarin phenols. Caffeate, 5-hydroxyferulate and daphnetin are not substrates. Cu2+, Zn2+ and Co2+ cause enzyme inhibition. (see also EC 2.1.1.70, 8-hydroxyfuranocoumarin 8-O-methyltransferase)
Form
Liquid or lyophilized powder
Enzyme Commission Number
CAS No.
67339-12-2, 101637-31-4
Storage
Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Synonyms
furanocoumarin 5-methyltransferase; furanocoumarin 5-O-methyltransferase; bergaptol 5-O-methyltransferase; bergaptol O-methyltransferase; bergaptol methyltransferase; S-adenosyl-L-methionine:bergaptol O-methyltransferase; BMT; S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5-O-methyltransferase
Reaction
(1) S-adenosyl-L-methionine + a 5-hydroxyfurocoumarin = S-adenosyl-L-homocysteine + a 5-methoxyfurocoumarin (general reaction); (2) S-adenosyl-L-methionine + bergaptol = S-adenosyl-L-homocysteine + bergapten
Notes
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
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