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Enzymes for Research, Diagnostic and Industrial Use

ABT-888

Cat No.
CEI-0636
Description
Potent inhibitor of PARP-1 and PARP-2 (potency ≤5 nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and radio-potentiation. Does not show inherent cytotoxicity and shows no single agent activity in tumor models.
Appearance
Orange solid
Product Overview
A PRP-1 and PARP-2 inhibitor
CAS No.
912445-05-7
Molecular Weight
242.27
Purity
>98% by TLC
Storage
-20 centigrade
Targets
Protein Synthesis
Molecular Formula
C₁₃H₁₆N₄O.2HCl
Chemical Name
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide . dihydrochloride
Solubility
DMSO (100 mM) or EtOH (50 mM)
Shipping Conditions
Gel pack
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