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Atomoxetine HCl

Cat No.
CEI-1225
Product Overview
Atomoxetine HCl is a selective norepinephrine transporter inhibitor (Ki= 5 nM). Norepinephrine transporter is a multi-pass membrane protein that is essential for norepinephrine reuptake into presynaptic nerve terminals and regulates norepinephrine homeostasis. Atomoxetine blocked coupling of radioligands to clonal cell lines that transfected with human norepinephrine transporter, serotonin and dopamine transporters with Ki= 5, 77 and 1451 nM respectively. In microdialysis studies in rat, atomoxetine increases extracellular levels of norepinephrine transporter in prefrontal cortex 3-fold without altering 5-HTEX levels. Atomoxetine also increases DAEX concentrations in PFC 3-fold without altering DAEX in striatum or nucleus accumbens. Comparing with methylphenidate, atomoxetine do not increase DA in striatum or nucleus accumbens, indicating it would not have motoric or drug abuse liabilities.
CAS No.
82248-59-7
Molecular Weight
291.82
Purity
0.98
Storage
Store at-20°C
Targets
Norepinephrine transporter
Molecular Formula
C17H22ClNO
Chemical Name
(3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine; hydrochloride
Solubility
Soluble in DMSO > 10 mM
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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