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Caspase-1 from Human, Recombinant

Cat No.
NATE-0813
Description
Caspase 1/Interleukin-1 converting enzyme is an enzyme that proteolytically cleaves other proteins, such as the precursor forms of the inflammatory cytokines interleukin 1β and interleukin 18, into active mature peptides. Caspase 1 has been shown to induce cell necrosis or pyroptosis and may function in various developmental stages. Studies of a similar protein in mouse suggest a role in the pathogenesis of Huntington's disease. Alternative splicing of the gene results in five transcript variants encoding distinct isoforms. Recent studies implicated caspase 1 in promoting CD4 T-cell death and inflammation by HIV, two signature events that fuel HIV disease progression to AIDS.
Abbr
CASP1, Recombinant (Human)
Alias
CASP1
Source
E. coli
Species
Human
Product Overview
Recombinant, human caspase-1 fused at the N-terminus to a His•Tag sequence and expressed in E. coli Useful for the study of enzyme regulation, cleavage of target substrates, and inhibitor screening.
Form
Liquid
Activity
>25,000 units/mg protein
Molecular Weight
10 kDa and 20 kDa
Purity
>90% by SDS-PAGE
Unit Definition
One unit is defined as the amount of enzyme that will cleave 1.0 pmol Ac-YVAD-NA per min at 30°C, pH 7.4.
Storage
< -70°C; Avoid freeze/thaw
Buffer
In 100 mM NaCl, 50 mM HEPES, 10 mM DTT, 1 mM EDTA, 10% glycerol, 0.5% CHAPS, pH 7.4.
Synonyms
CASP1; ICE; IL1BC; P45; Caspase 1; Interleukin-1; IL-1β Converting Enzyme
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