Products

Enzymes for Research, Diagnostic and Industrial Use

Leukotriene A4 Hydrolase from Human, Recombinant

Cat No.
NATE-0419
Description
Leukotriene A4 Hydrolase human (LTA4H) is a bifunctional zinc metalloenzyme that converts LTA4 into Leukotriene B4, and also demonstrates aminopeptidase activity. Leukotriene B4 is a lipid chemoattractant that plays critical roles in inflammaton, immune responses, host defenses against infections, and lipid homeostasis. Inhibition of LTA4H in a mouse model decreases LTB4 in the airways and attenuates airway inflammation and airway hyperreactivity through modulation of T cell and dendritic cell function.
Abbr
LTA4H, Recombinant (Human)
Alias
LTA4H; LTA4
Source
E. coli
Species
Human
Applications
Leukotriene A4 Hydrolase human (LTA4H) is a drug target for anti-inflammation, and for cancer prevention and therapy. It is also suitable for screening inhibitors of Leukotriene B4 synthesis. LTA4H is used to study allergic asthma and airway hyperresponsiveness
Product Overview
contains C-terminal his-tag
Form
Supplied as a solution in 100mM Tris, pH 8.0, containing 20% glycerol and 100mM potassium chloride.
Enzyme Commission Number
EC 3.3.2.6
CAS No.
90119-07-6
Molecular Weight
mol wt ~69 kDa
Storage
−70°C
Pathway
Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Eicosanoid Synthesis, organism-specific biosystem; Leukotriene synthesis, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem
Function
aminopeptidase activity; binding; epoxide hydrolase activity; epoxide hydrolase activity; leukotriene-A4 hydrolase activity; leukotriene-A4 hydrolase activity; metal ion binding; metallopeptidase activity; peptidase activity; zinc ion binding
Synonyms
leukotriene-A4 hydrolase; LTA-4 hydrolase; LTA4; LTA4 hydrolase; LTA4H; leukotriene A4 hydrolase; EC 3.3.2.6; 90119-07-6
Download Datasheet:


“LTA4H” Total Products Page

Inquiry
Realted Products
Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogEXWM-4003
EC No.EC 3.3.2.6
CAS No.90119-07-6
Source
Online Inquiry
Name:
*Phone:
*E-mail Address:
Country:
Company/Institution:
*Products or Services Interested:
Quantity:
Project Description:
Our Products are Not Intended for Private Therapeutic Use!
*Verification Code:
Please input "enzymes"(case insensitive) as verification code.

Welcome! For price inquiries, please feel free to contact us through the form below through the form on the left side. We will get back to you as soon as possible.

Sitemap  Privacy Policy
Copyright ©2011 - 2017 Creative Enzymes.
Contact Us 45-1 Ramsey Road, Shirley, NY 11967, USA
Email: info@creative-enzymes.com
Tel: 1-631-562-8517 1-631-448-7888
Fax: 1-631-938-8127
Distributors To view the contact information for a specific location, select the desired country: