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mycocerosate synthase

Cat No.
EXWM-2050
Description
This mycobacterial enzyme loads long-chain fatty acyl groups from their CoA esters and extends them by incorporation of three or four methylmalonyl (but not malonyl) residues, to form tri- or tetramethyl-branched fatty-acids, respectively, such as 2,4,6,8-tetramethyloctacosanoate (C32-mycocerosate). Since the enzyme lacks a thioesterase domain, the products remain bound to the enzyme and require additional enzyme(s) for removal. Even though the enzyme can accept C6 to C20 substrates in vitro, it prefers to act on C14-C20 substrates in vivo.
Form
Liquid or lyophilized powder
Enzyme Commission Number
CAS No.
95229-19-9
Storage
Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Synonyms
mas (gene name); mycocerosic acid synthase; acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)
Reaction
(1) a long-chain acyl-CoA + 3 methylmalonyl-CoA + 6 NADPH + 6 H+ + mycocerosate synthase = a trimethylated-mycocerosoyl-[mycocerosate synthase] + 4 CoA + 3 CO2 + 6 NADP+ + 3 H2O; (2) a long-chain acyl-CoA + 4 methylmalonyl-CoA + 8 NADPH + 8 H+ + mycocerosate synthase = a tetramethylated-mycocerosoyl-[mycocerosate synthase] + 5 CoA + 4 CO2 + 8 NADP+ + 4 H2O
Notes
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
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