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Native Streptococcus pyogenes Streptolysin O

Cat No.
NATE-0671
Description
Streptolysin O possesses a single polypeptide chain with a molecular weight of f62 kDa. Streptolysin O binds to membrane cholesterol and oligomerizes to create a ring structure that consists of 45 to 50 units. The ring structure inserts into the membrane to make a large pore (25 to 30 nm), which DNA, RNA, peptides and proteins may pass. It is thiol-activated. It is inhibited by allicin, an active component of garlic.
Abbr
SLO, Native (Streptococcus pyogenes)
Alias
SLO
Source
Streptococcus pyogenes
Applications
Permeabilizes membranes to permit cellular uptake of large or charged molecules. Streptolysin O is a toxin secreted by Streptococcus pyogenes and is a prototype member of poreforming bacterial cytolysins. It is used permeabilize cell membranes to permit cellular uptake of large or charged molecules. It is used to study macromolecule delivery. It is a potential anticancer agent and is used to study suicide cancer gene therapy.
Form
lyophilized powder
CAS No.
98072-47-0
Molecular Weight
69 kDa
Composition
Protein, ~3% Lowry
Unit Definition
One unit will cause 50% lysis of 2% red blood cell suspensions in phosphate buffered saline, pH 7.4, after incubation at 37°C for 30 min.
Storage
2-8°C
Synonyms
Streptolysin O; 98072-47-0; SLO
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ProductName
EC No.
CAS No.
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Price
CatalogNATE-1161
EC No.EC.3.2.2.5
CAS No.9032-65-9
SourceEscherichia coli
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