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Enzymes for Research, Diagnostic and Industrial Use

Chondroitinase ABC

Official Full Name
Chondroitinase ABC
Background
Chondroitinase ABC catalyzes the eliminative degradation of polysaccharides containing (1-4)-β-D-hexosaminyl and (1-3)-β-D-glucuronosyl or (1-3)-α-L-iduronosyl linkages to disaccharides containing 4-deoxy-β-D-gluc-4-enuronosyl groups. It acts on chondroitin 4-sulfate, chondroitin 6-sulfate, and dermatan sulfate, and acts slowly on hyaluronate. The molecular weight is found to be approximately 120 kDa with 2 non-identical subunits of molecular masses 86 kDa and 32 kDa. The pH optimum is found to be 8.0 with chondroitin sulfate and 6.8 with hyaluronic acid and tempeRature optimum is 37°C. 1 mM Zn2+ acts as an inhibitor, while 0.05 M acetate is an activator of the enzyme.
Synonyms
EC 4.2.2.4, chondroitinase; chondroitin ABC eliminase; chondroitinase ABC; chondroitin ABC lyase; chondroitin sulfate ABC lyase; ChS ABC lyase; chondroitin sulfate ABC endoeliminase; chondroitin sulfate ABC endolyase; ChS ABC lyase I; 9024-13-9

Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogEXWM-5096
EC No.EC 4.2.2.20
CAS No.9024-13-9
Source
CatalogNATE-1548
EC No.EC 4.2.2.20
CAS No.
SourceE. coli
CatalogNATE-0131
EC No.EC 4.2.2.4
CAS No.9024-13-9
SourceProteus vulgari...
Related Protocols
chondroitinase_abc -Enzymatic Assay Protocol
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