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Granzyme B

Official Full Name
Granzyme B
Background
Granzyme B, a 247 amino acid polypeptide, contains a leader sequence, which is cleaved by a signal peptidase and a two amino acid prodomain, which is cleaved by the lysosomal cysteine protease DPPI. The recombinant granzyme B is expressed in Pichia pastoris as the mature form and appears on SDS-PAGE as a triplet (~34, 32, and 30 kDa) due to three different glycosylations. Granzyme B, a serine protease, is the most prominent granzyme in a family of 11 found in the cytotoxic granules. The granzymes enter the target cell with the assistance of perforin, a critical molecule of the cytotoxic granules. In the target cell, the granzymes act on specific substrates involved with the cell death via apoptosis.
Synonyms
granzyme B; CTLA1; CCPII; cytotoxic cell proteinase-1; granzyme G; granzyme H; CCP1 proteinase; GzmB

Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogEXWM-4171
ProductNamegranzyme B
EC No.EC 3.4.21.79
CAS No.143180-74-9
Source
CatalogNATE-1622
EC No.EC 3.4.21.79
CAS No.143180-74-9
SourceYeast
CatalogNATE-0333
EC No.
CAS No.143180-74-9
SourcePichia pastoris
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