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Granzyme B

Official Full Name
Granzyme B
Background
Granzyme B, a 247 amino acid polypeptide, contains a leader sequence, which is cleaved by a signal peptidase and a two amino acid prodomain, which is cleaved by the lysosomal cysteine protease DPPI. The recombinant granzyme B is expressed in Pichia pastoris as the mature form and appears on SDS-PAGE as a triplet (~34, 32, and 30 kDa) due to three different glycosylations. Granzyme B, a serine protease, is the most prominent granzyme in a family of 11 found in the cytotoxic granules. The granzymes enter the target cell with the assistance of perforin, a critical molecule of the cytotoxic granules. In the target cell, the granzymes act on specific substrates involved with the cell death via apoptosis.
Synonyms
granzyme B; CTLA1; CCPII; cytotoxic cell proteinase-1; granzyme G; granzyme H; CCP1 proteinase; GzmB
Catalog Product Name EC No. CAS No. Source Price
EXWM-4171 granzyme B EC 3.4.21.79 143180-74-9 Inquiry
NATE-1622 Granzyme B from Human, Recombinant EC 3.4.21.79 143180-74-9 Yeast Inquiry
NATE-0333 Granzyme B from Mouse, Recombinant 143180-74-9 Pichia pastoris Inquiry