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tPA

Official Full Name
tPA
Background
Tissue plasminogen activator (abbreviated PLAT or tPA) is a secreted serine proteasewhich converts the proenzymeplasminogento plasmin, a fibrinolyticenzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin. This enzyme plays a role in cell migrationand tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysiswhich can result in thrombosisor embolism.
Synonyms
Tissue-type plasminogen activator; EC 3.4.21.68; tPA; t-PA; t-plasminogen activator; TPA; T-PA

Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogEXWM-4159
EC No.EC 3.4.21.68
CAS No.139639-23-9
Source
CatalogNATE-0920
EC No.EC 3.4.21.68
CAS No.
SourceCHO
Related Protocols
Tissue Plasminogen Activator -Enzymatic Assay Protocol

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