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5-Lipoxygenase from human, Recombinant


Cat No.
NATE-1249
Description
Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is an enzyme that in humans is encoded by the ALOX5 gene. Arachidonate 5-lipoxygenase is a member of the lipoxygenase family of enzymes. It transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases.
Abbr
5-LOX, Recombinant (Human)
Alias
5-LOX
Source
S9 insect cells
Species
Human
Form
A solution in 100 mM Tris-HCl, pH 8.0, containing 5 mM EGTA, 1mM CaCl2, and 30% glycerol
Enzyme Commission Number
EC 1.13.11.34
Activity
1,259.96 U/ml
CAS No.
80619-02-9
Molecular Weight
78 kDa
Unit Definition
One unit of enzyme consumes one nmol of oxygen per minute at 25°C in 50 mM Tris-HCl buffer, pH 7.5, containing 100 µM arachidonate, 2 mM CaCl2, 1 mM ATP.
Stability
As supplied, 6 months from the QC date provided on the Certificate of Analysis, when stored properly
Storage
at -80°C
Synonyms
Arachidonate 5-lipoxygenase; ALOX5; 5-lipoxygenase; 5-LOX; 5-LO; 5LPG; LOG5
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