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Enzymes for Research, Diagnostic and Industrial Use

Adriamycin (Doxorubicin)

Cat No.
CEI-0290
Description
Adriamycin (Doxorubicin) is a inhibitor of DNA topoisomerase II.
CAS No.
25316-40-9
Molecular Weight
579.98
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
topoisomerase II
Molecular Formula
C27H29NO11.HCl
Chemical Name
(8S,10S)-10-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride
Solubility
DMSO 116 mg/mL Water 116 mg/mL Ethanol
In vitro
Doxorubicin (DOX) is an anti-tumour agent. Adniamycin inhibits both cellular DNA and RNA synthesis. Doxorubicin can inhibit MCF-7 and MDA-MB231 with IC50 of 1 uM and 2 uM.
In vivo
Doxorubicin can treat non-Hodgkins lymphoma, multiple myeloma, acute leukemias, Kaposi sarcoma, Ewing sarcoma, Wilm tumor, and cancers of the breast, adrenal cortex, endometrium, lung, ovary, and other sites. It is sometimes used to treat non-cancerous conditions as well.
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