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Enzymes for Research, Diagnostic and Industrial Use

Bitopertin (R enantiomer)

Cat No.
CEI-1246
Product Overview
R enantiomer of RG1678. RG1678 (Bitopertin) is a potent and noncompetitive glycine reuptake inhibitor (GlyT1). Recent Phase II data shows that RG1678 is effective in reducing the negative symptoms when given in combination with second generation antipsychotics. RG1678 is currently in Phase III trials for the treatment of the negative symptoms of schizophrenia.
CAS No.
845614-12-2
Molecular Weight
543.46
Purity
0.98
Storage
Store at -20°C
Synonyms
RG1678 (R enantiomer); RG 1678 (R enantiomer); RG-1678 (R enantiomer); RO4917838 (R enantiomer)
Targets
Glycine reuptake
Molecular Formula
C21H20F7N3O4S
Chemical Name
[4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-[5-methylsulfonyl-2-[(2R)-1,1,1-trifluoropropan-2-yl]oxyphenyl]methanone
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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