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c-FMS inhibitor

Cat No.
CEI-1275
Description
c-FMS inhibitor is a potent, orally active and small-molecule inhibitor of FMS kinase with IC50 value of 0.8 nM.
Product Overview
c-FMS inhibitor, 4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylpiperidin-1-yl) phenyl]-1H-pyrrole-2-carboxamide, is a novel FMS kinase inhibitors as anti-inflammatory agents with an IC50 value of 0.8 nM. c-FMS inhibitor resulted in identification of a highly potent series of 2,4-disubstituted arylamides. It served as a proof-of-concept candidate in a collagen-induced model of arthritis in mice. c-FMS inhibitors has a potential to form reactive metabolites which are transformed into a series with equivalent potency by incorporation of carbon-based replacement groups. Structure-based model provides the framework to efficiently effect this transformation and restore potencies to previous levels. This optimization removed a risk factor for potential idiosyncratic drug reactions.
CAS No.
885704-21-2
Molecular Weight
406.52
Purity
0.98
Storage
Store at -20°C
Synonyms
1H-Pyrrole-2-carboxamide
Targets
FMS kinase
IC50
0.8 nM
Molecular Formula
C23H30N6O
Chemical Name
4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylpiperidin-1-yl)phenyl]-1H-pyrrole-2-carboxamide
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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