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Enzymes for Research, Diagnostic and Industrial Use

CH5424802

Cat No.
CEI-0022
Description
CH5424802
CAS No.
1256580-46-7
Molecular Weight
482.62
Purity
>99%
Storage
2 years at -20 centigrade
Targets
ALK
Molecular Formula
C30H34N4O2
Solubility
No
In vitro
CH5424802 prevents autophosphorylation of ALK in NCI-H2228 NSCLC cells expressing EML4-ALK. CH5424802 also suppresses the phosphorylation of STAT3 and AKT, but not of ERK1/2. CH5424802 completely inhibits the phosphorylation of STAT3 at Tyr705. CH5424802 is preferentially efficacious against NCI-H2228 cells expressing EML4-ALK, but not ALK fusion-negative NSCLC cell lines, including HCC827 cells (EGFR exon 19 deletion), A549 cells (KRAS mutant), or NCI-H522 cells (EGFR wild-type, KRAS wild-type, and ALK wild-type) in monolayer culture.
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