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CMP-Sialic Acid, Monosodium Salt

Cat No.
CSUB-0778
Description
CMP-sialic acid, Monosodium salt is the active form of sialic acid. In mammalian cells it has been shown to be required for the biosynthesis of sialic acid-containing complex carbohydrates. Loss of CMP sialic acid, Monosodium salt production or the feed back inhibitor of CMP-sialic acid has lead to gram scale production of sialic acid by GLCNE (GNE, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase). The compound has demonstrated the ability to neutralize various toxins through masking binding sites. CMP-sialic acid, Monosodium salt has also provided protection against gonococci by siaylation of Gal beta 1-4GlcNAc group. Catalyzed through a surface sialyl-transferase, CMP-Sialic Acid, Monosodium Salt enhanced the responsiveness of insulin. The compound has also displayed function in blood protein half-life regulation, protection against glycoprotein lysis and cellular adhesion. CMP-Sialic Acid, Monosodium Salt is a substrate of Sialyltransferase.
Applications
A toxin/gonococci protector; blood regulator
Form
Solid
CAS No.
3063-71-6
Molecular Weight
636.43
Purity
>85%
Storage
Store at -20° C
Synonyms
CMP-N-Acetylneuraminic Acid, Na
Molecular Formula
C20H30N4O16P·Na
MDL Number
MFCD00151579
Solubility
Soluble in water.
Substrates
Collagenase
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