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CPA inhibitor

Cat No.
CEI-1294
Description
CPA inhibitor is a potent inhibitor for carboxypeptidase A (CPA)
Product Overview
CPA inhibitor (carboxypeptidase inhibitor) is a potent inhibitor of EGFR. EGFR (epidermal growth factor receptor) is a member of ErbB family of receptors and binds to the members of EGF-family. It has been reported that EGFR aberrant expression is correlated with cancer, inflammatory disease, monogenic disease and so on. When tested with human pancreatic adenocarcinoma cell lines Capan-1, CPA inhibitor treatment significantly inhibited cells growth at the concentration more than 10 μg/ml and pre-treatment markedly inhibited cell proliferation rate. In A431 and MDA-MB-453 cell lines, pre-treated with CPA inhibitor markedly suppressed EGFR expression level. In nude mouse model with Capan-1 cells subcutaneous xenograft, administration of CPA inhibitor significantly reduced solid tumor growth without side effect.
CAS No.
223532-02-3
Molecular Weight
313.36
Purity
0.98
Storage
Store at -20°C
Synonyms
carboxypeptidase inhibitor
Targets
CPA
Molecular Formula
C18H19NO4
Chemical Name
2-benzyl-3-[hydroxy-(2-phenylacetyl)amino]propanoic acid
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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