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Cystathionine β Synthase from Human, recombinant

Cat No.
NATE-1667
Description
Cystathionine-β-synthase, also known as CBS, is an enzyme (EC 4.2.1.22) that in humans is encoded by the CBS gene. CBS uses the cofactor pyridoxal-phosphate (PLP) and can be allosterically regulated by effectors such as the ubiquitous cofactor S-adenosyl-L-methionine (adoMet). This enzyme belongs to the family of lyases, to be specific, the hydro-lyases, which cleave carbon-oxygen bonds. CBS is a multidomain enzyme composed of an N-terminal enzymatic domain and two CBS domains. The CBS gene is the most common locus for mutations associated with homocystinuria.
Abbr
CBS, Recombinant (Human)
Source
E. coli
Species
Human
Form
Liquid
Enzyme Commission Number
EC 4.2.1.22
Activity
100 U/mg
Molecular Weight
61.9 kDa (1-551 aa, NT His Tag)
Purity
> 90% by SDS-PAGE
Unit Definition
One unit is defined as the amount of enzyme required to convert 1.0 nmole of L-homocysteine to cystathionine and hydrogen sulfide per minute in 200 mM Tris pH 8.6 at 37 °C.
Stability
Stable for at least 1 year as supplied. Avoid repeated freeze and thaw cycles.
Storage
Store at –20°C.
Synonyms
Cystathionine-β-synthase; CBS; EC 4.2.1.22; 9023-99-8; Cystathionine β-synthase; Beta-thionase; methylcysteine synthase; serine sulfhydrase
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