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Enzymes for Research, Diagnostic and Industrial Use

DPP IV Inhibitor, NVP DPP 728

Cat No.
CEI-0463
Description
A potent, selective, reversible, and slow binding dipeptidyl peptidase IV inhibitor (IC50 = 14 nM). Displays>15,000 fold selectivity over DPP-II and a range of Proline-cleaving proteases. Displays anti-diabetic activity in vivo, improves glucose tolerance, increases glucagon-like peptide 1 (GLP-1) and insulin levels, and augments insulin secretion and GLUT-2 levels.
Alias
6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitrile Dihydrochloride
Appearance
White to off-white solid
Product Overview
A potent DPP IV Inhibitor,
CAS No.
247016-69-9
Molecular Weight
544.43
Purity
>98% by HPLC
Storage
-20 centigrade
Synonyms
6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitrile Dihydrochloride
Targets
DPP4
Molecular Formula
C₁₅H₁₈N₆O.2HCl
Chemical Name
6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitrile Dihydrochloride
Solubility
H₂O (~50 mg/ml)
Shipping Conditions
Gel pack
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