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Emetine dihydrochloride

Cat No.
CEI-0635
Description
A bitter-tasting crystalline alkaloid,derived from ipecac root and used in the treatment of amebiasis and as an emetic.Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Also, selectively inhibits multiple glioblastoma (GBM) stem cells-enriched cultures.
Appearance
White solid
Product Overview
A protein synthesis inhibitor
CAS No.
316-42-7
Molecular Weight
635.51
Purity
>98% by HPLC
Storage
+4 centigrade
Targets
Protein Synthesis
Molecular Formula
C₂₉H₄₀N₂O₄·2HCl
Chemical Name
2S,3R,11bS)-2-{[(1R)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline
Solubility
Water (>10 mg/ml)
Shipping Conditions
RT
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