Products

Enzymes for Research, Diagnostic and Industrial Use

Epothilone B (EPO906)

Cat No.
CEI-0288
Description
Epothilone B stabilizes microtubuli of macrophages from NMRI mice.Epothilone B can bind to microtubules with IC50 of 3.3 uM
CAS No.
152044-54-7
Molecular Weight
507.68
Purity
>99%
Storage
2 years at -20 centigrade
Targets
Tubulin
Molecular Formula
C27H41NO6S
Chemical Name
(1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione
Solubility
DSMO 102 mg/mL Water
In vitro
Epothilone B stabilizes microtubuli of macrophages from NMRI mice.Epothilone B can bind to microtubules with IC50 of 3.3 uM In multidrug-resistant CCRF-CEM/VBL100 cells, IC50 values for epothilone B is 2 uM. Epothilone B can inhibit Hs578T, Hela, KB3-1, and KBV-1 with IC50 of 3 nM to 92 nM by inducing mitotic arrest.
In vivo
EpoBis highly toxic to mice and showed little therapeutic effect when compared with desoxyepothilone B.
Download Datasheet:



Inquiry
Online Inquiry
Name:
*Phone:
*E-mail Address:
Country:
Company/Institution:
*Products or Services Interested:
Quantity:
Project Description:
Our Products are Not Intended for Private Therapeutic Use!
*Verification Code:
Please input "enzymes"(case insensitive) as verification code.

Welcome! For price inquiries, please feel free to contact us through the form below through the form on the left side. We will get back to you as soon as possible.

Sitemap  Privacy Policy
Copyright ©2011 - 2017 Creative Enzymes.
Contact Us 45-1 Ramsey Road, Shirley, NY 11967, USA
Email: info@creative-enzymes.com
Tel: 1-631-562-8517 1-631-448-7888
Fax: 1-631-938-8127
Distributors To view the contact information for a specific location, select the desired country: