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Etodolac

Cat No.
CEI-1331
Product Overview
Etodolac (Lodine) is a selective Cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 53.5 nM. Etodolac, a non-steroidal anti-inflammatory drug (NSAID), has been reported to treat osteoarthritis and rheumatoid arthritis. Etodolac was able to abolish the cell size decrease and block caspase-3/7 activity in TNFα-induced isolated rabbit articular chondrocytes. However, studies have shown that etodolac at 24h could induce cell death in human malignant rhabdoid tumor cells (FRTK-1) in a dose-dependent manner. Additionally, etodolac has shown to increase caspase-8,-9 and-3 activity 3 at 24 or 48 h in FRTK-1.
CAS No.
41340-25-4
Molecular Weight
287.35
Purity
0.98
Storage
Store at-20°C
Targets
COX-2
Molecular Formula
C17H21NO3
Chemical Name
2-(1,8-diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid
Solubility
Soluble in DMSO > 10 mM
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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