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Enzymes for Research, Diagnostic and Industrial Use

FK-228(Romidepsin)

Cat No.
CEI-0370
Description
Unlike TSA, the active form redFK of Romidepsin strongly inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 25 nM and 790 nM, respectively. Romidepsin is 17-23 times weaker than redFK in inhibiting these HDACs with IC50 of 36 nM, 47 nM, 510 nM, and 14 uM, respectively.
CAS No.
128517-07-7
Molecular Weight
540.7
Purity
>99%
Storage
2 years at -20 centigrade
Targets
HDAC
Molecular Formula
C24H36N4O6S2
Chemical Name
Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide
Solubility
DMSO 10 mg/mL,Water
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