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FK-866
Cat No.
CEI-0591
Description
Cell-permeable. FK-866 is a highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT) (Ki = 0.4 nM), causing gradual NAD+ depletion. NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators. NAD+ depletion by FK-866 directs delayed cell death by apoptosis in Hep-G2 human liver carcinoma cells (IC50 = ~1 nM).
Appearance
White to off-white solid
Product Overview
A highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT)
CAS No.
658084-64-1
Molecular Weight
718.1
Purity
>97% by HPLC
Storage
-20 centigrade
Targets
NAMPT
Molecular Formula
C₂₄H₂₉N₃O₂
Chemical Name
N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide
Solubility
DMSO or EtOH
Shipping Conditions
Gel pack
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