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Enzymes for Research, Diagnostic and Industrial Use

GSK256066

Cat No.
CEI-0231
Description
GSK256066
CAS No.
801312-28-7
Molecular Weight
518.58
Purity
>99%
Storage
2 years at -20 centigrade
Targets
PDE4B
Molecular Formula
C27H26N4O5S
Solubility
No
In vitro
GSK256066 is a slow and tight binding inhibitor of PDE4B with apparent IC50 of 3.2 pM. GSK256066 is an extremely potent inhibitor of LPS-stimulated TNFalpha production in PBMCs with pIC50 of 11.0 and IC50 of 10 pM and human whole-blood cultures with pIC50 of 9.90 and IC50 of 126 pM.
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