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Enzymes for Research, Diagnostic and Industrial Use

GSK-25

Cat No.
CEI-1127
Description
GSK-25 has promising oral bioavailability (49% in rat and 19% in monkey) a good half-life (1.8h in rat and 2.2h in monkey) and maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50=398nM, p70S6K IC50=1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).
Abbr
GSK-25(RPS6KA1, RPS6KB1)
Alias
RP11-492M19.2, HU-1, MAPKAPK1A, RSK, RSK1
CAS No.
874119-56-9
Molecular Weight
513.33
Purity
> 95%
Stability
2 years -20 centigrade Powder
1 month -4 centigrade in DMSO
More than one month -80 centigrade in DMSO
Storage
4 centigrade
Synonyms
RP11-492M19.2, HU-1, MAPKAPK1A, RSK, RSK1
Targets
RSK1, p70S6K
IC50
398nM, 1000nM
Molecular Formula
C24H16Cl2F2N6O
Chemical Name
4-(4-chloro-2-fluorophenyl)-2-(2-chloropyridin-4-yl)-N-(6-fluoro-1H-indazol-5-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide
Solubility
DMSO > 112mg/mL Water >1mg/mL Ethanol > 4mg/mL
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