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Garcinol

Cat No.
CEI-0598
Description
Garcinol is a polyisoprenylated benzophenone derivative isolated from Garcinia indica. It is a potent inhibitor of histone acetyltransferases (HATs) p300 (IC50 = 7 µM) and PCAF (IC50 = 5 µM) both in vitro and in vivo. HAT activity-dependent chromatin transcription was inhibited by garcinol, but it had no effect on naked DNA transcription. Moreover, it induces apoptosis in several types of cancer cells and has anti-inflammatory actions. Garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells.
Alias
Camboginol
Appearance
Yellow solid
Product Overview
A potent histone acetyltransferases (HATs) p300 inhibitor
CAS No.
78824-30-3
Molecular Weight
480.9
Purity
>98% by TLC
Storage
-20 centigrade
Synonyms
Camboginol
Targets
EP300, KAT2B
Molecular Formula
C 38 H 50 O 6
Solubility
DMSO (100 mM) or H2O (100 mM)
Shipping Conditions
Gel pack
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