Glucokinase from Escherichia coli, Recombinant

Cat No.

NATE-1571

Description

Glucokinase (EC 2.7.1.2) is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in the liver, pancreas, gut, and brain of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.

Abbr

GCK, Recombinant (Escherichia coli)

Alias

GCK

Source

E. coli

Species

Escherichia coli

Form

3.2 M ammonium sulphate

Enzyme Commission Number

EC 2.7.1.2

Activity

5.8 U/mg protein, 98.6 U/ml.

CAS No.

9001-36-9

Molecular Weight

35 kDa

Purity

>95% as judged by SDS-PAGE

Specificity

Glucose

Optimum pH

7.5

Optimum temperature

25 °C

Storage

Glucokinase should be stored at 4 °C, remaining stable up to 3 years under these storage conditions.

Synonyms

EC 2.7.1.2; glucokinase; glucokinase (phosphorylating); 9001-36-9; GCK; FGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2

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