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IC-87114

Cat No.
CEI-0141
Description
IC-87114 can inhibit PI3K-delta with IC50 of 500 nM.
CAS No.
371242-69-2
Molecular Weight
397.43
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
PI3K-delta
Molecular Formula
C22H19N7O
Chemical Name
2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one
Solubility
DMSO 0.66 mg/mL Water
In vitro
IC87114 is a selective PI3K-delta selectivity relative to the other class I PI3Ks. The IC50 of IC87114 for PI3K-delta inhibition was 0.5 uM whereas the IC50 values for PI3K-alpha, PI3K-beta, and PI3K-gamma were 100 uM, 75 uM, and 29 uM, respectively. IC87114 is 58-fold more selective for PI3K-delta relative to PI3K-gamma, and over 100-fold selective relative to PI3K-alpha and PI3K-beta.
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