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IRAK inhibitor 4

Cat No.
CEI-1376
Description
IRAK inhibitor 4 is an inhibitor of interleukin-1 receptor-associated kinase.
Product Overview
IRAK inhibitor 4 is an inhibitor of interleukin-1 receptor-associated kinase. IRAK-4 belongs to Interleukin-1 Receptor-Associated Kinase, which are key components in the signal transduction pathways. IRAK-4 is an essential signal transducer downstream of interleukin-1 receptor (IL-1R), interleukin-18 receptor (IL-18R) and Toll-like receptors (TLRs). Inhibition of IRAK-4 can modulate its function, thus toning down inflammatory responses. IRAK inhibitor 4 is an indazole inhibitor. As inhibitors of IRAK-4, imidazo[1,2-b]pyridazines and indazoles are used for treatment of some inflammatory, cell proliferative and immune-related disorders.
CAS No.
1012104-68-5
Molecular Weight
620.66
Purity
0.98
Storage
Store at -20°C
Targets
IRAK
Molecular Formula
C33H35F3N6O3
Chemical Name
1-(4-hydroxycyclohexyl)-N-(3-methylbutyl)-2-[[5-[2-(trifluoromethoxy)phenyl]-1H-indazol-3-yl]amino]benzimidazole-5-carboxamide
Solubility
Soluble in DMSO
Shipping Conditions
Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request
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