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Enzymes for Research, Diagnostic and Industrial Use

Indirubin

Cat No.
CEI-0096
Description
Indirubin
CAS No.
479-41-4
Molecular Weight
262.26
Purity
>99%
Storage
2 years at -20 centigrade
Targets
CDK
Molecular Formula
C16H10N2O2
Solubility
No
In vitro
Indirubin, a bis-indole obtained from various natural sources, is responsible for the reported antileukemia activity of a Chinese Medicinal recipe, Danggui Longhui Wan.A dramatic cytostatic effect, as measured by actual cell counts and associated with a sharp G1 phase arrest, is induced by 1-methyl-indirubins, a subfamily of AhR-active but kinase-inactive indirubins.In the time-course experiment, CYP1A1 mRNA is induced by indirubin transiently. Indirubin was also metabolized by CYP1A1 and lost its ligand activity. Indirubin would appear to be a good substrate of CYP1A1 given its low dissociation constant.Levels of cytochrome P450 1A1/2 proteins and mRNAs in the liver of mice dosed with indirubin were also enhanced.
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