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JAK3 Inhibitor VI

Cat No.
CEI-1067
Description
A cell-permeable 3′-pyridyl oxindole compound that acts as a potent and reversible inhibitor of JAK3 (IC50 = 27 nM)and displays ~16-fold greater selectivity over JAK2. Binds to the enzyme active site and prevents IL-2-induced cellular phosphorylation of JAK3 and STAT5. Inhibits IL-2-induced cell proliferation (IC50 = 760 and 250 nM for mouse CTLL and human T-cells, respectively) and alleviates oxazolone-induced ear odema in mouse with an efficacy comparable to that of Dexamethasone (Cat. No. 265005).
Abbr
JAK3 Inhibitor VI(JAK3, CTLL, human T-cells)
Alias
JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
CAS No.
856436-16-3
Molecular Weight
383.4
Purity
>98% by HPLC
Storage
+2 centigrade to +8 centigrade
Synonyms
JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
Targets
JAK-3, mouse CTLL, human T-cells
IC50
27 nM, 760 nM, 250 nM
Molecular Formula
C18H13N3O • MeSO3H
Solubility
DMSO or H2O
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