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JNJ-38158471

Cat No.
CEI-1132
Description
It is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50=40nM. It also inhibits closely related tyrosine kinases, Ret (180nM) and Kit (500nM). It has no significant activity (>1 microM) against VEGFR-1 and VEGFR-3.
Abbr
JNJ-38158471(KDR)
Alias
CD309, FLK1, VEGFR, VEGFR2
CAS No.
951151-97-6
Molecular Weight
364.79
Purity
> 95%
Stability
2 years -20 centigrade Powder
1 month -4 centigrade in DMSO
More than one month -80 centigrade in DMSO
Storage
4 centigrade
Synonyms
CD309, FLK1, VEGFR, VEGFR2
Targets
VEGFR-2
IC50
40nM
Molecular Formula
C15H17ClN6O3
Chemical Name
(E)-1-(4-(6-amino-5-((methoxyimino)methyl)pyrimidin-4-yloxy)-2-chlorophenyl)-3-ethylurea
Solubility
DMSO > 112mg/mL Water >1mg/mL Ethanol > 4mg/mL
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