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Jervine

Cat No.
CEI-0663
Description
Cell-permeable. Structurally similar to cyclopamine. Inhibits the sonic hedgehog (shh) pathway by interacting with smoothened. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Tomatidine is a useful negative control.
Appearance
Yellow solid
Product Overview
A sonic hedgehog (Shh) pathway inhibitor
CAS No.
469-59-0
Molecular Weight
442.94
Purity
>97% by HPLC
Storage
-20 centigrade
Targets
SHH
Molecular Formula
C27H39NO3
Chemical Name
2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,1­1bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexad­ecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H­-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1­H)-one
Solubility
DMSO (10 mM)
Shipping Conditions
Gel pack
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