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Enzymes for Research, Diagnostic and Industrial Use

L-685, 458

Cat No.
CEI-0705
Description
Cell-permeable. A potent and selective γ-secretase inhibitor (IC50 = 17 nM) .Displays> 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of Aβ40 and Aβ42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells).
Appearance
White solid
Product Overview
A γ-secretase inhibitor
CAS No.
292632-98-5
Molecular Weight
461.55
Purity
>98% by TLC
Storage
2-8 centigrade
Targets
gamma-secretase
Molecular Formula
C₃₉H₅₂N₄O₆
Chemical Name
5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-( 2R)-benzylhexanoyl)-L-leucyl-L-phenylalaninamide
Solubility
DMSO (100 mM)
Shipping Conditions
RT
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