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L-NAME hydrochloride

Cat No.
CEI-0592
Description
A pro-drug of L- NG-Nitro-L-arginine (L-NOARG). Hydrolysis of the methyl ester of L-NAME by cellular esterases converts it into a fully functional L-NOARG that exhibits some selectivity for inhibition of neuronal and endothelial NOS isoforms (Ki values of 15 nM, 39 nM, and 4.4 µM for nNOS (bovine), eNOS (human), and iNOS (mouse), respectively). L-NAME inhibits cGMP formation in endothelial cells with an IC50 of 3.1 µM (in the presence of 30 µM arginine) and reverses the vasodilation effects of acetylcholine in rat aorta rings with an EC₅₀ of 0.54 µM.
Alias
NG-Nitro-L-arginine methyl ester hydrochloride
Appearance
White to off-white solid
Product Overview
A pro-drug of the NOS inhibitor L- NG-Nitro-L-arginine
CAS No.
51298-62-5
Molecular Weight
278.35
Purity
>99% by TLC
Storage
-20 centigrade
Synonyms
NG-Nitro-L-arginine methyl ester hydrochloride
Targets
NOS1, NOS3, Nos2
Molecular Formula
C 7 H 15 N 5 O 4 . HCl
Solubility
DMSO (~200 mg/ml) or Ethanol (~40 mg/ml)
Shipping Conditions
Gel pack
Amino Acid Sequence
H-Arg(NO2)-OMeHCl
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CAS No.214358-33-5
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