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Merck 5

Cat No.
CEI-1097
Description
Merck 5 is a potent and reversible ATP-competitive inhibitor of the JAK kinases Jak1, Jak2, Jak3, and Tyk2. It also blocks IL2 and IL4 dependent proliferation of CTLL cells and inhibits the phosphorylation of STAT5.
Abbr
Merck 5(Jaks )
Product Overview
ATP-competitive inhibitor of the JAK kinases Jak1, Jak2, Jak3, and Tyk2.
CAS No.
457081-03-7
Molecular Weight
309.34
Purity
> 95%
Stability
2 years -20 centigrade Powder
1 month -4 centigrade in DMSO
More than one month -80 centigrade in DMSO
Storage
4 centigrade
Targets
Jaks
Molecular Formula
C18H16FN3O
Chemical Name
6-dihydro-7H-Benz[h]imidazo[4,5-f]isoquinolin-7-one, 2-(1,1-dimethylethyl)-9-fluoro-1
Solubility
DMSO > 112mg/mL Water >1mg/mL Ethanol > 4mg/mL
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