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Muramyl dipeptide (MDP)
Cat No.
LIGC-009
Description
Muramyl dipeptide (MDP) is the minimal bioactive peptidoglycan motif common to all bacteria, the essential structure required for adjuvant activity in vaccines. MDP has been shown to be recognized by NOD2, but not TLR2, nor TLR2/1 or TLR2/6 associations. This recognition is highly stereospecific of the L-D isomer, excluding any reaction to the D-D or L-L analogs. The potent adjuvant activity of MDP may be linked to an activation of the CIAS1/NALP3/Cryopyrin inflammasome.
Form
Lyophilized powder
CAS No.
53678-77-6
Molecular Weight
492.5
Concentration
Working concentration: 10 ng - 10 µg/ml
Specificity
NOD2 agonist
Stability
Product is stable 6 months at -20°C when properly stored. Avoid repeated freeze-thaw cycles.
Storage
Store at -20°C. Upon resuspension, aliquote MDP and store at -20°C.
Synonyms
N-Acetylmuramyl-L-Alanyl-D-Isoglutamine (L-D isoform); Muramyldipeptide (L-D isomer, active); Muramyl dipeptide; MDP
Molecular Formula
C19H32N4O11
Solubility
10 mg/ml in water
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