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Native Burkholderia sp. Lipoprotein Lipase

Cat No.
NATE-0417
Description
Lipoprotein lipase (LPL) (EC 3.1.1.34) is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase, and endothelial lipase. It is a water-soluble enzyme that hydrolyzes triglycerides in lipoproteins, such as those found in chylomicrons and very low-density lipoproteins (VLDL), into two free fatty acids and one monoacylglycerol molecule. It is also involved in promoting the cellular uptake of chylomicron remnants, cholesterol-rich lipoproteins, and free fatty acids. LPL requires ApoC-II as a cofactor. LPL is attached to the luminal surface of endothelial cells in capillaries by the protein glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1) and by heparin sulfated proteoglycans. It is most widely distributed in adipose, heart, and skeletal muscle tissue, as well as in lactating mammary glands.
Abbr
LPL, Native (Burkholderia sp.)
Alias
LPL
Source
Burkholderia sp.
Applications
Lipoprotein lipase has been used in a study to assess the role of lipogenic enzymes in colorectal cancer. It has also been used in a study to investigate lipasemic activity of low molecular weight heparin in rats.
Product Overview
Lipoprotein lipase hydrolyzes triglycerides in plasma lipoproteins causing release of fatty acids for metabolic purposes in muscles and adipose tissue.
Form
lyophilized powder
Enzyme Commission Number
EC 3.1.1.34
Activity
> 50,000 units/mg solid
CAS No.
9004-02-8
Unit Definition
One unit will release 1.0 nmole of p-nitrophenol per min at pH 7.2 at 37°C using p-nitrophenyl butyrate as substrate.
Storage
−20°C
Synonyms
lipoprotein lipase; clearing factor lipase; diglyceride lipase; diacylglycerol lipase; postheparin esterase; diglyceride lipase; postheparin lipase; diacylglycerol hydrolase; lipemia-clearing factor; EC 3.1.1.34; 9004-02-8; LPL
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Realted Products
Catalog
ProductName
EC No.
CAS No.
Source
Price
CatalogDIA-210
EC No.EC 3.1.1.34
CAS No.9004-02-8
SourcePseudomonas sp.
CatalogDIA-211
EC No.EC 3.1.1.34
CAS No.9004-02-8
SourceMicroorganism
CatalogDIA-282
EC No.
CAS No.
SourcePseudomonas species
CatalogNATE-0416
EC No.EC 3.1.1.34
CAS No.9004-02-8
SourceBovine milk
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Realted Service
Realted Protocols
lipoprotein lipase -Enzymatic Assay Protocol
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