Description
Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer’s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced.
Enzyme Commission Number
EC 3.4.23.5
Activity
120 U/mg protein
Synonyms
CTSD; cathepsin D; CLN10; CPSD; HEL-S-130P; EC 3.4.23.5; 9025-26-7
Solubility
Distilled water or dilute buffer