Description
In enzymology, a bilirubin oxidase (EC 1.3.3.5) is an enzyme that catalyzes the chemical reaction:2 bilirubin + O2↔ 2 biliverdin + 2 H2O. Thus, the two substRates of this enzyme are bilirubin and O2, whereas its two products are biliverdin and H2O. This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-CH group of donor with oxygen as acceptor. This enzyme participates in porphyrin and chlorophyll metabolism.
Abbr
Bilirubin Oxidase, Native (Myrothecium verrucaria)
Source
Myrothecium verrucaria
Applications
Bilirubin oxidase is used to degrade bilirubin. Bilirubin oxidase, from Myrothecium verrucaria, may be used to determine free hemoglobin in icteric specimens. It also has potential application in dye effluent decolorization and is a potential treatment for neonatal jaundice.
Enzyme Commission Number
EC 1.3.3.5
Activity
15-65 units/mg protein
Unit Definition
One unit will oxidize 1.0 μmole of bilirubin per min at pH 8.4 at 37°C.
Synonyms
bilirubin oxidase M-1; EC 1.3.3.5; 80619-01-8; Bilirubin:oxygen oxidoreductase; Bilirubin Oxidase
